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Observational study of haloperidol in hospitalized patients with COVID-19.
Hoertel N, Sánchez-Rico M, Vernet R, Jannot AS, Neuraz A, Blanco C, Lemogne C, Airagnes G, Paris N, Daniel C, Gramfort A, Lemaitre G, Bernaux M, Bellamine A, Beeker N, Limosin F; AP-HP/Universities/INSERM Covid-19 research collaboration and AP-HP Covid CDR Initiative. Hoertel N, et al. PLoS One. 2021 Feb 19;16(2):e0247122. doi: 10.1371/journal.pone.0247122. eCollection 2021. PLoS One. 2021. PMID: 33606790 Free PMC article. Clinical Trial.
BACKGROUND: Haloperidol, a widely used antipsychotic, has been suggested as potentially useful for patients with COVID-19 on the grounds of its in-vitro antiviral effects against SARS-CoV-2, possibly through sigma-1 receptor antagonist effect. M …
BACKGROUND: Haloperidol, a widely used antipsychotic, has been suggested as potentially useful for patients with COVID-19 on t …
Observational Study of Chlorpromazine in Hospitalized Patients with COVID-19.
Hoertel N, Sánchez-Rico M, Vernet R, Jannot AS, Neuraz A, Blanco C, Lemogne C, Airagnes G, Paris N, Daniel C, Gramfort A, Lemaitre G, Bernaux M, Bellamine A, Beeker N, Limosin F; AP-HP/Universities/INSERM COVID-19 Research Collaboration and AP-HP COVID CDR Initiative. Hoertel N, et al. Clin Drug Investig. 2021 Mar;41(3):221-233. doi: 10.1007/s40261-021-01001-0. Epub 2021 Feb 9. Clin Drug Investig. 2021. PMID: 33559821 Free PMC article.
INTRODUCTION: Chlorpromazine has been suggested as being potentially useful in patients with coronavirus disease 2019 (COVID-19) on the grounds of its potential antiviral and anti-inflammatory effects. OBJECTIVE: The aim of this study was to examine the assoc …
INTRODUCTION: Chlorpromazine has been suggested as being potentially useful in patients with coronavirus disease 2019 (COVID- …
Association of Antihypertensive Agents with the Risk of In-Hospital Death in Patients with Covid-19.
Chouchana L, Beeker N, Garcelon N, Rance B, Paris N, Salamanca E, Polard E, Burgun A, Treluyer JM, Neuraz A; AP-HP/Universities/Inserm COVID-19 research collaboration, AP-HP Covid CDR Initiative, and “Entrepôt de Données de Santé” AP-HP Consortium”. Chouchana L, et al. Cardiovasc Drugs Ther. 2022 Jun;36(3):483-488. doi: 10.1007/s10557-021-07155-5. Epub 2021 Feb 17. Cardiovasc Drugs Ther. 2022. PMID: 33595761 Free PMC article.
PURPOSE: The role of angiotensin receptor blockers (ARB), angiotensin-converting enzyme inhibitors (ACEi), or other antihypertensive agents in the case of Covid-19 remains controversial. We aimed to investigate the association between antihypertensive agent exposure …
PURPOSE: The role of angiotensin receptor blockers (ARB), angiotensin-converting enzyme inhibitors (ACEi), or other antihypertensive agents …
Association between antidepressant use and reduced risk of intubation or death in hospitalized patients with COVID-19: results from an observational study.
Hoertel N, Sánchez-Rico M, Vernet R, Beeker N, Jannot AS, Neuraz A, Salamanca E, Paris N, Daniel C, Gramfort A, Lemaitre G, Bernaux M, Bellamine A, Lemogne C, Airagnes G, Burgun A, Limosin F; AP-HP / Universities / INSERM COVID-19 Research Collaboration and AP-HP COVID CDR Initiative. Hoertel N, et al. Mol Psychiatry. 2021 Sep;26(9):5199-5212. doi: 10.1038/s41380-021-01021-4. Epub 2021 Feb 4. Mol Psychiatry. 2021. PMID: 33536545
A prior meta-analysis showed that antidepressant use in major depressive disorder was associated with reduced plasma levels of several pro-inflammatory mediators, which have been associated with severe COVID-19. Recent studies also suggest that several antidepressan …
A prior meta-analysis showed that antidepressant use in major depressive disorder was associated with reduced plasma levels of several pro-i …
What level of D-dimers can safely exclude pulmonary embolism in COVID-19 patients presenting to the emergency department?
Revel MP, Beeker N, Porcher R, Jilet L, Fournier L, Rance B, Chassagnon G, Fontenay M, Sanchez O; AP-HP /Universities/Inserm COVID-19 research collaboration, AP-HP Covid CDR Initiative. Revel MP, et al. Eur Radiol. 2022 Apr;32(4):2704-2712. doi: 10.1007/s00330-021-08377-9. Epub 2022 Jan 7. Eur Radiol. 2022. PMID: 34994845 Free PMC article.
OBJECTIVES: To identify which level of D-dimer would allow the safe exclusion of pulmonary embolism (PE) in COVID-19 patients presenting to the emergency department (ED). METHODS: This retrospective study was conducted on the COVID database of Assistance Publ …
OBJECTIVES: To identify which level of D-dimer would allow the safe exclusion of pulmonary embolism (PE) in COVID-19 patients …
External validation of prognostic scores for COVID-19: a multicenter cohort study of patients hospitalized in Greater Paris University Hospitals.
Lombardi Y, Azoyan L, Szychowiak P, Bellamine A, Lemaitre G, Bernaux M, Daniel C, Leblanc J, Riller Q, Steichen O; AP-HP/Universities/INSERM COVID-19 Research Collaboration AP-HP COVID CDR Initiative. Lombardi Y, et al. Intensive Care Med. 2021 Dec;47(12):1426-1439. doi: 10.1007/s00134-021-06524-w. Epub 2021 Sep 28. Intensive Care Med. 2021. PMID: 34585270 Free PMC article.
PURPOSE: The Coronavirus disease 2019 (COVID-19) has led to an unparalleled influx of patients. ...We aim to externally validate existing prognostic scores for COVID-19. METHODS: We used "COVID-19 Evidence Alerts" (McMaster Univers …
PURPOSE: The Coronavirus disease 2019 (COVID-19) has led to an unparalleled influx of patients. ...We aim to externally …
Natural Language Processing for Rapid Response to Emergent Diseases: Case Study of Calcium Channel Blockers and Hypertension in the COVID-19 Pandemic.
Neuraz A, Lerner I, Digan W, Paris N, Tsopra R, Rogier A, Baudoin D, Cohen KB, Burgun A, Garcelon N, Rance B; AP-HP/Universities/INSERM COVID-19 Research Collaboration; AP-HP COVID CDR Initiative. Neuraz A, et al. J Med Internet Res. 2020 Aug 14;22(8):e20773. doi: 10.2196/20773. J Med Internet Res. 2020. PMID: 32759101 Free PMC article.
However, although this idea has often been suggested, no opportunity has arisen to actually test it in real time. The current coronavirus disease (COVID-19) pandemic presents such an opportunity. ...CONCLUSIONS: In our study, use of calcium channel blockers w …
However, although this idea has often been suggested, no opportunity has arisen to actually test it in real time. The current coronavirus …
Obesity Doubles Mortality in Patients Hospitalized for Severe Acute Respiratory Syndrome Coronavirus 2 in Paris Hospitals, France: A Cohort Study on 5,795 Patients.
Czernichow S, Beeker N, Rives-Lange C, Guerot E, Diehl JL, Katsahian S, Hulot JS, Poghosyan T, Carette C, Jannot AS; AP-HP / Universities / INSERM COVID-19 research collaboration and AP-HP COVID CDR Initiative. Czernichow S, et al. Obesity (Silver Spring). 2020 Dec;28(12):2282-2289. doi: 10.1002/oby.23014. Epub 2020 Nov 6. Obesity (Silver Spring). 2020. PMID: 32815621 Free PMC article.
METHODS: This is a prospective cohort study including 5,795 patients aged 18 to 79 years hospitalized from February 1 to April 30, 2020, in the Paris area, with confirmed infection by severe acute respiratory syndrome coronavirus 2. Adjus …
METHODS: This is a prospective cohort study including 5,795 patients aged 18 to 79 years hospitalized from February 1 to April 30, 2020, in …
Correction to: Association of Antihypertensive Agents with the Risk of In-Hospital Death in Patients with Covid-19.
Chouchana L, Beeker N, Garcelon N, Rance B, Paris N, Salamanca E, Polard E, Burgun A, Treluyer JM, Neuraz A; AP-HP/Universities/Inserm COVID-19 research collaboration, AP-HP Covid CDR Initiative, and “Entrepôt de Données de Santé” AP-HP Consortium. Chouchana L, et al. Cardiovasc Drugs Ther. 2022 Dec;36(6):1255. doi: 10.1007/s10557-021-07164-4. Cardiovasc Drugs Ther. 2022. PMID: 33661434 Free PMC article. No abstract available.